Schedule

8am-9am: Welcome

9am-9.15am: Opening words from the ONCOLille institute director, and from the organizing committee president.

9.15am-10.15am - session 1 “Intrinsic factors of persister cells”

Co-chairs: Dr Dimitra Gkika (ONCOLille Institute), Dr David Tulasne (ONCOLille Institute)

• Dr Leslie Duplaquet (ONCOLille Institute, France)
  • "Plasticity in Small Cell Lung Cancer: From Mechanisms to Therapeutic Vulnerabilities" 
• Remi Tellier (ONCOLille Institute, France)
  • "MET exon 14 skipping disables apoptotic dependence receptor function to promote kinase-independent tumor survival"
• Dheeraj Kannancheri Puthooru (ONCOLille Institute, France)
  • "Calcium Channels in Prostate Cancer Drug Resistance"

10.15am-10.30am Sponsors presentations

10.30am-11.00am Coffee break

11.00am-12.30am session 2 ” Mathematical Modeling and AI for the Study of Cellular Persistence in Cancer”

Co-chairs: Dr Alexandre Poulain (ONCOLille Institute), Dr Gabriel Monsalve (ONCOLille Institute)

• Pr Shensi Shen (Department of Thoracic Surgery and Institute of Thoracic Oncology, National Clinical Research Center for Geriatrics, Chengdu, China)
  • "The double face of translation initiation factors in drug-tolerant persister cells."
• Dr Carrere Cécile (Orléans University, France)
  • "Metronomic Chemotherapy Modulates Clonal Interactions to Prevent Drug Resistance in Non-Small Cell Lung Cancer : Mathematical model and predictions."
• Dr Jan Ramon (ONCOLille Institute, France)
  • "Trustworthy Federated AI for cancer research"
• Dr Tulasne David (ONCOLille Institute, France)
  • Comprehensive map of the regulatory network triggered by MET exon 14 skipping reveals important involvement of the RAS-ERK signaling pathway

12.30am-2pm Lunch

2pm-3.30pm Posters (even numbers)

3.30pm-5pm session 3 ”Personalized medicine: strategies to overcome tumor persistence” 

Co-chairs: Dr Anthony Turpin (Lille CHU), Pr Caroline Robert (Paris Saclay University)

• Dr Philippe Cassier (Centre Léon Bérard, Lyon, France)
  • “Reversion of the EMT in cancers”
• Dr Simon Baldacci (ONCOLille Institute, France)
  • “Targeting residual disease in oncogene-addicted lung cancers”
• Mayar Soussi (ONCOLille Institute, France)
  • "TRPM2 channel increases cell viability of triple negative breast cancer cells following chemotherapy through increased mitochondrial activity"
• Tristan Girgin (ONCOLille Institute, France)
  • "A new paradigm to target tyrosine kinase receptors in pancreatic adenocarcinoma : development of new combined therapies targeting MUC4 EGF domains"

5pm-5.30pm Coffee break

5.30pm-7pm session 4 ”Microenvironment and persister cells”

Co-chairs: Pr Nadira Delhem (ONCOLille Institute), Pr Laurent Mortier (CHU Lille)

• Pr Caroline Robert (Gustave Roussy, France)
  •  “How do Persister cells evade the immune system? “
• Pr Iradj SOBHANI (AP-HP Hôpital Henri Mondor , France)
  •  "Bacterial genotoxins and the tumor microenvironment: keys to targeted colorectal cancer therapy"
• Marie Boileau (ONCOLille Institute, France)
  • "Evaluation of the adjuvant immunomodulatory effect of Rose Bengal photodynamic therapy in human melanoma"
• Emma Bourdon (ONCOLille Institute, France)
  • "Implication of MUC1 in the microenvironment of lung cancer cells"

9am-10.30am session 5 ”Adaptation mechanisms: senescence and stemness”

Co-chairs: Dr Edith Bonnelye, Pr Christelle Cauffiez

• Dr Schmitt Clemens (Universitätsmedizin Berlin, Germany)
  • “Senescence-associated stemness - the driving principle of cancer cell persistence?”
• Pr Corinne Abbadie (ONCOLille Institute, France)
  • “Radio-induced senescence: a step towards second cancers post-radiotherapy”
• Adrien Pioger (ONCOLille Institute, France)
  • "Impact of O-GlcNAcylation on chemotherapy-induced senescence escape of colon cancer cells"
• Emilie Combémorel (ONCOLille Institute, France)
  • "Role of ATF6α in the establishment and effects of senescence"

10.30am-11am Coffee break - Group picture

11am-12am Plenary lecture

• Pr René Bernards (Netherlands Cancer Institute, The Netherlands)

  • "Two new ways to kill cancer cells"

12am-1.30pm Lunch

1.30pm-3.30pm Posters (odd numbers)

3.30pm-5pm session 6 ”Tumor on chips: new models and future directions”

Co-chairs: Dr Fabrice Soncin, Dr Loïc Lemonnier

• Dr Abdul Barakat (Institut Polytechnique de Paris, France)
  • “Angiogenesis-on-Chip: Role of Biophysical Factors in Angiogenic Sprouting”
• Dr Alessandro Furlan (ONCOLille Institute, France)
  • "Tumors-on-chips as pre-clinical models mimicking tumor microenvironment"
• Elyas Al Yasini (ONCOLille Institute, France) 
  • "Development of Metallic Nanoparticles for Plasmonic Photothermal Therapy Applied Alone or in Combination with Immunotherapy in the Treatment of Advanced-Stage Melanomas"
• Francesca Bianco (ONCOlille Institute, France)
  • "Modulation of ORAI1 Enhances the Efficacy of Photodynamic Therapy in Pancreatic Ductal Adenocarcinoma"

5pm-5.30pm best poster and best presentation awards, end of the meeting.